Description
Department PSD Chemistry: Faculty Support About the Department Krishnan Laboratory is at the forefront of applying DNA nanotechnology to target small molecules specifically diseased cells with organelle-level precision. Currently, our lab is developing high-accuracy, DNA-based probes for discovery biology by using them for high throughput screening. While you are here, your project will involve developing assays for CRISPR screening genetic models based on quantitative fluorescence outputs, for the discovery and characterization of new ion channels or transporters in organelles, that may impact neurodegenerative/cardiac / immune- related diseases. Job Summary The Staff Scientist will execute, facilitate, and promote advanced technical and scientific research projects within the Krishnan Lab. We are seeking a candidate who recognizes the need for innovation and develops or incorporates advances in assay development. This position will be conducting sequencing methods, as well as developing and testing hypotheses related to the molecular and cell biological functionality of candidate hits. Responsibilities Develop and support research and operations in macrophage phenotyping and genotyping, DNA nanodevice design and characterization and gene cloning. Conduct operation, development, and maintenance of tissue culture and the associated support equipment, including consumables and computational pipeline. Develop innate and adaptive immunological assays, multi-parameter flow cytometry as well as endocytic assays in various cell types. Assist GUV preparations and integrating them with DNA nanodevices for imaging and sensor testing. Develop innate and adaptive immunological assays, multi-parameter flow cytometry as well as endocytic assays in various cell types. Design, develop, and test new experimental workflows, instruments, and/or reagents for research (including hardware, software, statistical methods, etc.). Train and assist other lab users, as prescribed by the Principal Investigator, in all aspects of cell culture, and cell biological methods, molecular biology, image processing and data analysis. Participate in the preparation and writing of grant applications and reports, and co-authors scientific research manuscripts. May present work at scientific meetings and provide peer review of grant applications and scientific manuscripts. Perform other related work as needed, with respect to this and other related projects, data organization and management, procurement of research supplies, management of regulatory documents (IACUC/IBC). Collaborates with other researchers as appropriate. Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information. Leads the contributions to scientific writing and publications, including protocols and grants. Trains new laboratory personnel. Performs other related work as needed. Minimum Qualifications Education: Minimum requirements include a PhD in related field. Work Experience: Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline. Certifications: --- Preferred Qualifictions Education: PhD in Biology or Chemistry. Experience: Quantitative chemical imaging. CRISPR technology. Disease detection. Certifications: Previous postdoctoral experience. Preferred Competencies Knowledge of RNA-based molecular technologies, cell signaling, genetics, intracellular traffic and molecular biology, mechanisms of endocytosis, secretion and exocytosis. Knowledge of research techniques or methods complementary to live imaging, cloning and development of knockout and stable cell lines. Ability to work independently and as part of a team. Ability to train others. Knowledge of regulatory policies and procedures. Attention to detail. Organizational skills. Verbal and written communication skills. Ability to handle multiple tasks under performance and time-related stress. Working Conditions Physical exposure to allergens emanating from working with the model organisms of yeast, bacteria, C. elegans, zebrafish, and mice. Daily handling of common organic solvents and molecular biology grade consumables and wearing personal protection equipment. Application Documents Resume (required) Cover Letter (required) References (preferred) When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application. Job Family Research Role Impact Individual Contributor Scheduled Weekly Hours 37.5 Drug Test Required No Health Screen Required No Motor Vehicle Record Inquiry Required No Pay Rate Type Salary FLSA Status Exempt Pay Range $69,000.00 - $80,000.00 The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting. Benefits Eligible Yes The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook. 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